| 2022-05-28 15:00:00May 28, 2022 | Thatch FC vs St Dominics | 4 - 6 | DDL Premier Division | 2022 | Albion Rovers Football Grounds | Recap | - |
| 2022-05-30 19:30:00May 30, 2022 | St Dominics vs Bellurgan United | 2 - 2 | DDL Premier Division | 2022 | Friary Field | Recap | - |
| 2022-06-13 19:30:00June 13, 2022 | St Dominics vs Shamrocks FC | 2 - 5 | DDL Premier Division | 2022 | Friary Field | Recap | - |
| 2022-06-22 19:30:00June 22, 2022 | Glenmuir United vs St Dominics | 4 - 2 | DDL Premier Division | 2022 | Hoeys Lane | Recap | - |
| 2022-06-27 19:30:00June 27, 2022 | St Dominics vs Faughart Rovers | 5 - 0 | DDL Premier Division | 2022 | Friary Field | Recap | - |
| 2022-07-04 19:30:00July 4, 2022 | St Dominics vs Rampart Celtic | 1 - 2 | DDL Premier Division | 2022 | Friary Field | Recap | - |
| 2022-07-18 19:15:53July 18, 2022 | St Dominics vs Rock Celtic | 5 - 1 | DDL Premier Division | 2022 | Friary Field | Recap | - |
| 2022-08-08 19:00:59August 8, 2022 | St Dominics vs Bay FC | 3 - 0 | DDL Premier Division | 2022 | Friary Field | Recap | - |
| 2022-08-23 20:00:00August 23, 2022 | Quay Celtic vs St Dominics | 5 - 1 | DDL Premier Division | 2022 | Clancy Park | Recap | - |
| 2022-09-03 15:00:00September 3, 2022 | Carrick Rovers vs St Dominics | 3 - 0 | DDL Premier Division | 2022 | Ballybay Road | Recap | - |
